Nicolaus Bruno J. R.
Born 1928.
– Ph.D. in Organic Chemistry, University of Zürich (CH), Faculty of Sciences (1954).
Assistant to Nobel Prize Laureate Prof. Paul Karrer University of Zürich (1949-1952);Lecturer of Organic Chemistry University of Milano Italy (1962-1970); Associate Professor of Pharmaceutical Chemistry University of Perugia Italy (1978); Pharmaceutical Industrial Advisor to the United Nations (1966).
More than 100 publication and 50 patents. Fluent in Italian, German, French English and Spanish.
– Member of several cultural and scientific associations: New Swiss Chemical Society; Società Italiana di Scienze Farmaceutiche (SISF); International College of Neuropsychopharmacology (CINP); European College of Neuropsychopharmacology (ECNP); International Psychogeriatric Association (IPA); Academia Medicinae et Psychiatriae Foundation – New York; Associazione Italiana Malattia di Alzheimer – AIMA; Society of Literature and Science – John Hopkins University Baltimore USA; Associazione Sanitari Artisti Letterati Italiani (ASLAI); Associate Editor of Integrative Psychiatry; Swiss Society of the History of Medicine and Sciences; Gruppo Nazionale di Fondamenti e Storia della Chimica, GNFSC; Chemical Heritage Foundation –The Beckman Center for History of Chemistry Philadelphia USA; Centro di Studi Storici Valchiavennaschi, Pro Raetia; Verein Kulturraum Viamala; CICAP – Scienza e Paranormale; Accademia Pontaniana Napoli; New York Academy of Sciences.
– Attended various international congresses dealing with drug research and development (chemistry, biology, pharmacology, clinics, economics).
Main scientific interests:
1948 – Chemical Pathology of the Brain, Neuropsychopharmacology, Learning and Memory, Brain Ageing, Antibiotics and Infections, Natural and Synthetic Pigments
Main achievements:
1950 – 1953 University of Zurich CH, Institute for Organic Chemistry (Prof. Paul Karrer):
Structure an synthesis of synthetic and natural pteridin pigments; new synthesis of biological polyamines from peptides, with lithiumaluminiumhydrid.
1954 – 1960 SANDOZ Basle: Research Chemist.
Synthesis of styryl-derivatives with peculiar structure/colour properties; improvement and application of TLC (thinlayerchromatography) to synthetic and natural pigments.
1960 – 1969 DOW-LEPETIT Milano: Senior Scientist, Director of new products development.
Separation and identification of transformation products of Rifamycin B; New microbiological determination of antibiotics on thinlayerchromatograms; synthesis of new organic hydroxylaminderivatives and new 4,5- and 7-membered heterocyclic compounds potentially active on the CNS; international development of new drugs: Rifamycin antibiotics (Rifamycin SV, Rifamide, Rifampicin); vitamin preparations in new dosage forms (agruvit, orangrip); spironolactone–diuretic, ovulen-contraceptive, amitryptiline –antidepressant, metoclopramide and sulpiride – peristalsis modulators.
1969 – 1990 ISF CORPOR (ISF, one of the leading Italian Pharma Companies belonging to the SMITHKLINE BEECHAM GROUP):
Vice President for Research and Development; Vice President of Innovation; Deputy General Manager; Vice President of the Board of Directors.
International Development of New Drugs: Pyrrolnitrin – antifungal, Bekanamycin – antibiotic, Trithiozine – antiulcer, Piromidic and Pipemidic acid, Norfloxacin – quinolonic antibacterials, Trimetoquinolbronchodilator, carbocalcitonin – calcium metabolism, Metolazone – diuretic, Cadralazine –antihypertensive, Oxiracetam – nootropic, Cefonicid – antibiotic, Rokitamycine –antibiotic.
1990 – 1995 MEDIATOR PHARMA CONSULTANTS (Agency for the development and licensing of new drugs and acquisition of companies): Chairman of the Scientific Advisory Board.
Studies on braindisfunctions and history of science; active participation to the decade of the brain activities (CINP; ECNP, IPA).
1996 – Free lancer and scientific consultant.
Further studies on history of science an braindevelopment; neuropsychopharmacology of brain pathologies and behaviour disturbances; New hypothesis on the causes of suicide and molecular disease of the brain; astrochemistry; speculations on the chemical nature of interstellar clouds and the origin of life in the universe.
Main Publications
1. P. KARRER, R. SCHWYZER, BRUNO J.R. NICOLAUS
80. Weitere Methyl-pteridinrot-ähnliche Farbstoffe aus verschiedenen Methyl-pteridinen und Pteridin.
HELV. CHIM. ACTA, 33, 557, 1950.
2. P. KARRER, BRUNO J.R. NICOLAUS, R. SCHWYZER
158. Über die Konstitution des Methyl-pteridinrots.
HELV. CHIM. ACTA, 33, 1233, 1950.
3. P. KARRER, BRUNO J.R. NICOLAUS
125. Zur Kenntnis des Methyl-pteridinrots, Pteridinrots und ähnlicher Farbstoffe.
HELV. CHIM. ACTA, 34, 1029, 1951.
4. P. KARRER, BRUNO J.R. NICOLAUS
199. Reduktionen einiger einfacher Peptide mit Lithiumaluminiumhydrid.
HELV. CHIM. ACTA, 35, 1581, 1952.
5. BRUNO J.R. NICOLAUS
I. Zur Kenntnis der Pteridinrot-Reihe und ähnlicher Farbstoffe.
II. Aliphatische Polyamine.
Inaugural-Dissertation der Universität von Zürich.
Brunner & Bodmer, Zürich 1954.
6. BRUNO J.R. NICOLAUS
“Anwendung der Dünnschichtchromatographie auf Pteridine”.
J.CHROMATOGR., 4, 384, 1960.
7. BRUNO J.R. NICOLAUS
“Nuovi coloranti a dispersione. Nota I. – Monoazoici gialli contenenti gruppi uretanici”.
REND. DELL’ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA’ NAZIONALE DI SCIENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 105, 1960.
8. BRUNO J.R. NICOLAUS
“Nuovi coloranti a dispersione. Nota II. – Eteri di monoazoici gialli contenenti gruppi uretanici”.
REND. DELL’ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA’ NAZIONALE DI SCIENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 122, 1960.
9. BRUNO J.R. NICOLAUS
“Nuovi coloranti a dispersione. Nota III. – Ammine aromatiche terziarie contenenti gruppi uretanici”.
REND. DELL’ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA’ NAZIONALE DI SCIENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 132, 1960.
10. BRUNO J.R. NICOLAUS
“Nuovi coloranti a dispersione. Nota IV. – Monoazoici rossi contenenti gruppi uretanici”.
REND. DELL’ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA’ NAZIONALE DI SCIENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 142, 1960.
11. BRUNO J.R. NICOLAUS
“Nuovi coloranti a dispersione. Nota V – Coloranti stirilici contenenti gruppi uretanici”.
REND. DELL’ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA’ NAZIONALE DI SCIENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 297, 1960.
12. BRUNO J.R. NICOLAUS
“Nuovi coloranti a dispersione. Nota VI – Nuovi composti stirilici e relazioni intercorrenti tra costituzione chimica e proprietà ottiche”.
REND. DELL’ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA’ NAZIONALE DI SCIENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 320, 1960.
13. BRUNO J.R. NICOLAUS
“Nuovi coloranti a dispersione. Nota VII – Composti stirilici basici e relazioni intercorrenti tra costituzione chimica e spettri di assorbimento”.
REND. DELL’ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA’ NAZIONALE DI SICENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 480, 1960.
14. P. SENSI, C. CORONELLI, BRUNO J.R. NICOLAUS
“Rifomycin”.
XII. Chromatographic Studies of Some Products of Transformation of Rifomycin B.
J. CHROMATOGR., 5, 519, 1961.
15. BRUNO J.R. NICOLAUS, L. MARIANI, E. TESTA
129. Auf das Zentralnervensystem wirkende Substanzen XXV Reaktionen der a-substituierten b-Lactone II. Eine neue allgemeine Synthese
a-substituierter Propionsäuren und deren Derivate.
HELV. CHIM. ACTA, 44, 1076, 1961.
16. BRUNO J.R. NICOLAUS, L. MARIANI, E. TESTA
256. Auf das Zentralnervensystem wirkende Substanzen XXVII Reaktionen mit a-substituierten b-Propiolactonen III. 4-Mono- und 4,4-disubstituierte 3-Pyrazolidinone.
HELV. CHIM. ACTA, 44, 2059, 1961.
17. BRUNO J.R. NICOLAUS, C. CORONELLI., A. BINAGHI
“Applicazione agli antibiotici della cromatografia su strato sottile”.
FARMACO, Prat., 16, 349, 1961.
18. BRUNO J.R. NICOLAUS, C. CORONELLI, A. BINAGHI
“Mikrobiologischer Nachweis von Antibiotika auf Dünnschichtchroma-
togrammen”.
EXPERIENTIA, 17, 473, 1961.
19. BRUNO J.R. NICOLAUS, E. TESTA
“Einfaches Verfahren zur Spaltung von Pikraten”.
ANGEWANDTE CHEMIE, 73, 655, 1961.
20. BRUNO J.R. NICOLAUS, L. MARIANI, E. TESTA.
Reaktionen mit a-substituierten b-Propiolactonen III. 4-Mono- und 4,4-disubstituierte 3-Pyrazolidinone.
CHIMIA, 15, 577, 1961.
21. BRUNO J.R. NICOLAUS, L. MARIANI, G. GALLO, E. TESTA
Reactions with a-Substituted b-Propiolactones. I. 4,4-Disubstituted 2-Oxazolidinones.
Research on Compounds Active on the Central Nervous System. XXIII^.
J. ORG. CHEM., 26, 2253, 1961.
22. BRUNO J.R. NICOLAUS, G. PAGANI, E. TESTA
40.0, N-substituierte Hydroxylamine
1. Mitteilung – Über das 0-(b-Hydroxyäthyl)-hydroxylamin, ein neuartiges Analogon von b-Aminoäthanol, und Derivate Untersuchungen über synthetische Arzneimittel I.
HELV. CHIM. ACTA, 45, 358, 1962.
23. BRUNO J.R. NICOLAUS, E. BELLASIO, E. TESTA.
85. Auf das Zentralnervensystem wirkende Substanzen XXIX.
Über neuartige schwefelhaltige Heterocyclen: 4,4-Dialkyl-1,2-thioazetidin-3-on-1,1-dioxide und 2,4,4-Trialkyl-1,2-thioazetidin-3-on-1,1-dioxide.
HELV. CHIM. ACTA, 45, 717, 1962.
24. BRUNO J.R. NICOLAUS, G. PAGANI, E. TESTA
162.0,n-substituierte Hydroxylamine
2.Mitteilung – Synthese und Eigenschaften der 0-(Phenylalkyl)-hydroxylamine.
Untersuchungen über synthetische Arzneimitteln II.
HELV. CHIM. ACTA, 45, 1381, 1962.
25. BRUNO J.R. NICOLAUS, E. BELLASIO, E. TESTA
47. Auf das Zentralnervensystem wirkende Substanzen XXXV.
Über neuartige schwefelhaltige Heterocyclen II: Synthese und Eigenschaften der 3-Alkoxy-4,4-dialkyl-4H-1,2-thiazet-1,1-dioxide.
HLEV. CHIM. ACTA, 46, 450, 1963.
26. E. TESTA, BRUNO J.R. NICOLAUS, L. MARIANI, G. PAGANI
85. 0,N-substituierte Hydroxylamine V.Mitt.
Über Synthese und Eigenschaften der a-Aminoxy-Carbonsäuren, Analoga natürlicher a-Aminocarbonsäuren.
HELV. CHIM. ACTA, 46, 766, 1963.
27. BRUNO J.R. NICOLAUS, E. BELLASIO, E. TESTA
“Sull’acido fenilsolfonacetico e suoi derivati funzionali”.
ANNALI DI CHIMICA, 53, 14, 1963.
28. BRUNO J.R. NICOLAUS, L. MARIANI, E. TESTA
“Idrossilamine 0,N-sostituite. Nota III. Una nuova sintesi delle 0-alchilidrossilamine. Ricerche su nuovi farmaci di sintesi 2.
ANNALI DI CHIMICA, 53, 281, 1963.
29. BRUNO J.R. NICOLAUS, L. MARIANI, G. PAGANI, MAFFII G. TESTA E.
“Idrossilamine 0.N-sostituite. Nota IV. Sintesi ed attività di alcuni analoghi idrossilaminici di anestetici locali”.
ANNALI DI CHIMICA, 53, 290, 1963.
30. BRUNO J.R. NICOLAUS, E. BELLASIO, G. PAGANI, E. TESTA.
“Sintesi e proprietà degli N-alcossi ed N-idrossi-azetidin-2-oni”.
GAZZETTA CHIMICA ITALIANA, 93, 618, 1963.
31. BRUNO J.R. NICOLAUS, L. MARIANI, E. BELLASIO, E. TESTA
“Nuovi aspetti della chimica dei 3-pirazolidinoni 4-mono e 4,4-disostituiti”.
GAZZETTA CHIMICA ITALIANA, 94, 652, 1964.
32. E. TESTA, BRUNO J.R. NICOLAUS, E. BELLASIO, L. MARIANI
Auf das Zentralnervensystem wirkende Substanzen XXXVII 1-Alkyl- und 1-Aryl-Azetidinone-(2).
JUSTUS LIEBIGS ANN. CHEM., 673, 71, 1964.
33. BRUNO J.R. NICOLAUS, E. BELLASIO, E. TESTA
New Pharmacologically Active Thiazetidine Compounds.
Patent
U.K.
:
963.500
Date
1964
34. BRUNO J.R. NICOLAUS, E. TESTA
New Anti-Bacterial 0-Hydroxy- or -Phenyl-Alkyloximes.
Patent
U.K.
:
964.721
Date
1964
35. BRUNO J.R. NICOLAUS, E. TESTA
Hydroxylamines substituées et procédés pour leur préparation.
Patent
France
:
1.320.965
Date
1963
”
Germany
:
1.148.559
Date
1963
”
Austria
:
23.30.01
Date
1964
36. BRUNO J.R. NICOLAUS, E. TESTA
4,4-Disubstituted 3-Pyrazolidinones and Therapeutic Compositions Containing the Same.
Patent
USA
:
3.166.568
Date
1965
”
U.K.
:
1.022.861
Date
1966
37. E. MERIAN, BRUNO J.R. NICOLAUS, W. WEHRLI
Water-Insoluble Monoazo Dyestuffs.
Patent
USA
:
2.831.850
Date
1958
”
France
:
1.146.212
Date
1957
”
Deutschland
:
1.061.924
Date
1960
”
Schweiz
:
33.21.36
Date
1958
”
U.K.
:
792.212
Date
1958
38. E. MERIAN, BRUNO J.R. NICOLAUS
Verfahren zur Herstellung wasserunlöslicher Monoazofarbstoffe.
Patent
Schweiz
:
34.09.27
Date
1959
”
Schweiz
:
34.41.50
Date
1960
”
Schweiz
:
34.41.51
Date
1960
”
Schweiz
:
34.41.52
Date
1960
39. E. MERIAN, BRUNO J.R. NICOLAUS, W. WEHRLI
Water-Insoluble Monoazo Dyestuffs.
Patent
USA
:
2.870.137
Date
1959
”
Schweiz
:
34.41.49
Date
1960
”
Schweiz
:
35.85.31
Date
1962
”
U.K.
:
816.308
Date
1959
40. BRUNO J.R. NICOLAUS, E. MERIAN
Water-Insoluble Monoazo Dyestuffs.
Patent
USa
:
2.864.816
Date
1958
”
France
:
1.177.377
Date
1959
”
Deutschland
:
1.061.925
Date
1959
”
U.K.
:
807.696
Date
1959
”
Schweiz
:
35.31.02
Date
1961
”
Schweiz
:
34.84.92
Date
1960
41. E. MERIAN, BRUNO J.R. NICOLAUS
N-Substituted Urea and Carbamate Derivatives of Water-Insoluble
Tertiary Amines.
Patent
USA
:
2.909.561
Date
1959
”
France
:
1.216.235
Date
1960
”
U.K.
:
845.220
Date
1960
”
Schweiz
:
35.37.32
Date
1961
”
Belgique
:
55.93.24
Date
1958
”
Italia
:
63.28.54
Date
1962
42. E. MERIAN, BRUNO J.R. NICOLAUS
Water-Insoluble Azo Dyestuffs.
Patent
USA
:
3.069.408
Date
1962
”
Deutschland
:
1.061.927
Date
1959
”
U.K.
:
824.443
Date
1959
”
Schweiz
:
34.57.05
Date
1960
”
France
:
1.216.235
Date
1960
”
Belgique
:
55.93.24
Date
1958
43. E. MERIAN, BRUNO J.R. NICOLAUS, O. SENN
New Water-Insoluble Stryryl Dyestuffs.
Patent
USA
:
2.850.520
Date
1958
”
Deutschland
:
1.067.156
Date
1960
”
Schweiz
:
35.85.34
Date
1962
”
France
:
1.216.235
Date
1960
”
U.K.
:
843.644
Date
1960
”
Belgique
:
55.93.24
Date
1958
”
Italia
:
57.73.74
Date
1956
”
Japan
:
28.64.29
44. E. MERIAN, BRUNO J.R. NICOLAUS, O. SENN
Water-Insoluble Styryl Dyestuffs.
Patent
USA
:
2.936.319
Date
1960
”
Deutschland
:
1.068.834
Date
1957
”
U.K.
:
843.643
Date
1960
”
France
:
1.187.779
Date
1959
”
Schweiz
:
34.66.35
Date
1960
”
Schweiz
:
35.16.96
Date
1961
”
Schweiz
:
35.13.58
Date
1961
45. EGGENBERGER H., E. MERIAN, BRUNO J.R. NICOLAUS
Dyeing of Man-Made Fibers in the Mass.
Patent
U.K.
:
843.645
Date
1960
”
Deutschland
:
1.061.955
Date
1960
”
France
:
1.182.373
Date
1959
46. E. MERIAN, BRUNO J.R. NICOLAUS, M. PERRIG, K. HOFER
Verfahren zum Färben und Bedrucken von Gebilden aus Polymerisaten oder Mischpolymerisaten auf Basis von Acrylnitril oder Vinylidencyanid.
Patent
Deutschland
:
1.090.171
Date
1961
”
France
:
1.206.872
Date
1960
”
Schweiz
:
34.95.76
Date
1960
”
U.K.
:
853.217
Date
1960
”
Italia
:
589.933
Date
1959
47. E. MERIAN, BRUNO J.R. NICOLAUS
Azo Dyestuffs of Low Solubility in Water.
Patent
USA
:
2.980.666
Date
1961
”
Deutschland
:
1.092.583
Date
1958
”
U.K.
:
851.910
Date
1960
”
Belgique
:
57.91.59
Date
1959
”
France
:
76.452
Date
1961
48. BRUNO J.R. NICOLAUS
Verfahren zur Herstellung neuer wasserunlöslicher Styrylfarbstoffe.
Patent
Schweiz
:
35.13.59
Date
1961
”
Belgique
:
57.30.04
Date
1958
49. E. MERIAN, BRUNO J.R. NICOLAUS, W. WEHRLI
Process for Dyeing Polyethylene Terephthalate of Fiber-Wool Blend.
Patent
USA
:
3.027.220
Date
1962
”
France
:
1.215.973
Date
1960
”
U.K.
:
895.427
Date
1962
”
Schweiz
:
35.06.34
Date
1961
50. BRUNO J.R. NICOLAUS
Colorants de Dispersion, leurs procédés de fabrication et leurs applications.
Patent
Belgique
:
57.47.80
Date
1959
51. BRUNO J.R. NICOLAUS
Colorants de Dispersion, leurs procédés de fabrication et leurs applications.
Patent
Belgique
:
57.47.81
Date
1959
52. BRUNO J.R. NICOLAUS, E. MERIAN
Nouvelles amines primaires de la série benzothiazolique et colorants mono-azoiques qui en dérivent, leur fabrication et leurs applications.
Patent
France
:
1.220.194
Date
1960
”
U.K.
:
868.037
Date
1961
”
Deutschland
:
1.113.772
Date
1962
53. BRUNO J.R. NICOLAUS
Nouveaux colorants azoiques hydrosolubles, leur procédé de fabrication et leurs applications.
Patent
Belgique
:
57.99.65
Date
1959
”
Italia
:
61.58.23
Date
1961
54. BRUNO J.R. NICOLAUS
Nouveaux colorants azoiques hydrosolubles, leur procédé de fabrication et leur préparation.
Patent
Belgique
:
58.01.61
Date
1959
”
Italia
:
61.58.22
Date
1961
55. R. HAHN, BRUNO J.R. NICOLAUS
Verfahren zur Herstellung basischer Styrylfarbstoffe.
Patent
Deutschland
:
1.103.485
Date
1961
”
France
:
1.240.138
Date
1960
”
Belgique
:
58.23.16
Date
1959
”
Italia
:
61.54.14
Date
1961
56. BRUNO J.R. NICOLAUS
Colorants basiques, leur procédé de fabrication et leurs applications.
Patent
France
:
1.240.748
Date
1960
”
U.K.
:
931.557
Date
1963
”
Belgique
:
58.30.02
Date
1959
”
Italia
:
61.73.93
Date
1961
”
Japan
:
30.85.42
57. BRUNO J.R. NICOLAUS
Verfahren zum Färben oder Bedrucken von textilen Gebilden aus Acrylnitrilpolymerisationsprodukten.
Patent
Schweiz
:
36.47.57
Date
1962
”
Belgique
:
58.44.59
Date
1958
”
Italia
:
62.58.62
Date
1961
58. BRUNO J.R.NICOLAUS
Nouveaux colorants azoiques quaternaires, leur procédé de fabrication et leurs applications.
Patent
France
:
1.244.711
Date
1960
”
Belgique
:
58.53.85
Date
1959
”
Italia
:
62.45.69
Date
1959
59. BRUNO J.R. NICOLAUS
Colorants basiques, leur procédé de fabrication et leurs applications.
Patent
France
:
1.246.068
Date
1960
”
Belgique
:
58.66.34
Date
1960
”
Japan
:
30.53.77
60. E. MERIAN, BRUNO J.R. NICOLAUS, O. SENN, W. WEHRLI
Colorants azoiques difficilement solubles dans l’eau, leurs procédés de fabrication et leurs applications.
Patent
France
:
1.264.972
Date
1961
”
Belgique
:
59.36.44
Date
1960
”
Italia
:
63.53.19
Date
1962
61. BRUNO J.R. NICOLAUS, E. TESTA
Process for preparing Hydroxylamines.
Patent
U.K.
:
986.213
Date
1965
”
France
:
1.377.484
Date
1964
62. E. TESTA, G. CIGNARELLA, G. PIFFERI, BRUNO J.R. NICOLAUS
a,a -Disubstituted Propionic Acids and their Derivatives.
Patent
U.K.
:
988.934
Date
1965
63. E. TESTA, G. CIGNARELLA, G. PIFFERI, BRUNO J.R. NICOLAUS
New Penicillins.
Patent
U.K.
:
988.933
Date
1965
”
USA
:
3.280.111
Date
1960
”
Deutschland
:
1.195.755
Date
1965
”
Schweiz
:
411.892
Date
1966
64. BRUNO J.R. NICOLAUS, E. TESTA
0-(b-Acyloxyethyl)-N,N-Dialkyl-Hydroxylamines.
Patent
USA
:
3.184.500
Date
1965
”
Austria
:
23.30.01
Date
1962
”
France
:
1.320.965
Date
1963
”
U.K.
:
1.017.601
Date
1966
65. E. TESTA, BRUNO J.R. NICOLAUS
Procédé de préparation des 2-azétidinones substituées en position 1.
Patent
France
:
1.393.833
Date
1965
”
Austria
:
25.03.74
Date
1966
66. BRUNO J.R. NICOLAUS, E. BELLASIO, G. PAGANI, L. MARIANI, E. TESTA
201. Über eine neue allgemeine Synthese von 3,3-disubstituierten 2,3,4,5-Tetrahydro-1H-(benzo [b] 1.4-diazepin)-2-onen durch Ringerweiterung 3,3-disubstituierter 1-(o-Aminophenyl)-azetidin-2-one.
HELV. CHIM. ACTA, 48, 1867, 1965.
67. BRUNO J.R. NICOLAUS, E. TESTA
Process for the preparation of Hydroxylamine Derivatives.
Patent
U.K.
:
1.042.191
Date
1966
68. BRUNO J.R. NICOLAUS, E. TESTA
Beta-Dialkylaminoxyethyl Esters of Substituted Benzoic Acids.
Patent
U.K.
:
1.017.602
Date
1966
69. BRUNO J.R. NICOLAUS
“Pteridin Chemistry”.
Lectures held at the University of Milan 1962-1963.
70. BRUNO J.R. NICOLAUS
“Recent acquisitions in antibiotics chemistry – The Tetracyclines”.
Lectures held at the University of Milan – 1963-1964.
71. BRUNO J.R. NICOLAUS
“Recent acquisitions in antibiotics chemistry – The Penicillins and Rifamycins”.
Lectures held at the University of Milan – 1964-1965.
72. BRUNO J.R. NICOLAUS
“Relationships between structure and activity”.
Lectures held at the University of Milan – 1965-1966.
73. BRUNO J.R. NICOLAUS
“Phenyl- and Bisphenylisochinolinalkaloids”.
Lectures held at the University of Milan – 1966-1967.
74. BRUNO J.R. NICOLAUS
“The antibiotics: an integrated approach on their chemistry, microbiology, pharmacology, and therapeutic application”.
Lectures held at the University of Perugia – 1988-1989.
75. BRUNO J.R. NICOLAUS
“New findings in the field of cognitive activators”.
Lectures held at the University of Perugia – 1988.
76. BRUNO J.R. NICOLAUS
“Tematiche di ricerca sviluppate dai Laboratori I.S.F. – Italseber negli ultimi sette anni”.
Atti del Simposio Internazionale GIRF/SISF la Ricerca Scientifica nell’Industria Farmaceutica in Italia – Risultati e Ruolo Internazionale – Roma, 2-4 Ottobre 1975.
77. BRUNO J.R. NICOLAUS
“Research Thematics Developed by I.S.F. – Italseber Laboratories over the Last Seven Years”.
International Symposium GIRF/SISF Scientific Research in the Pharmaceutical Industry in Italy – Results and International Role – Emme Print, Milan 1976.
78. BRUNO J.R. NICOLAUS
“Research Thematics Developed by ISf-Italseber Laboratories over the Last Seven Years” ISF-Laboratories for biomedical research, 1-31, 1975 – Tipografia Artigianelli.
79. BRUNO J.R. NICOLAUS
“Beitrag zur Chemie Organischer Hydroxylaminderivate”.
Bodmer Offset Verlag, Zürich 1976.
80. BRUNO J.R. NICOLAUS
“Beitrag zur Synthese von 4,5 und 7-Gliedrigen Heterocyclen mit einem Quartären Kohlenstoffatom”.
Bodmer Offset Verlag, Zürich 1976.
81. BRUNO J.R. NICOLAUS
“La ricerca, cofattore essenziale dello sviluppo di un’azienda”.
Convegno FAST/IMI: Per una Politica dell’Innovazione Tecnologica in Italia. Esperienze e Prospettive del Fondo per la Ricerca Applicata.
Roma, 5-6 Dicembre 1977.
82. BRUNO J.R. NICOLAUS
“Research Topics 1969-1978”.
ISF Laboratories for biomedical research – 1-66, 1979- Tipografia Artigianelli Milano.
83. BRUNO J.R. NICOLAUS
“Aspetti e prospettive della chimica farmaceutica”.
I Convegno Nazionale – Divisione di Chimica Farmaceutica della Società Chimica Italiana – Pisa, 13-15 Dicembre 1979.
84. F. SPARATORE, R. CAPASSO, M. MARCHETTI, BRUNO J.R. NICOLAUS, L. PARISELLA, V. TORTORELLA.
“Didattica e realtà professionale nel settore della chimica farmaceutica”.
Tavola Rotonda
II Convegno Nazionale – Divisione di Chimica Farmaceutica della Società Chimica Italiana – Padova, 18-20 Dicembre 1980.
85. BRUNO J.R. NICOLAUS
“Chemistry and pharmacology of nootropics”.
DRUG DEVELOPMENT RESEARCH, 2, 463-474, 1982, Editor Alan R. Liss Inc.
86. BRUNO J.R. NICOLAUS
“Research Topics 1969-1982”.
ISF – Laboratories for Biomedical Research 1-78, 1982, Grafiche F.G.F. Milano.
87. BRUNO J.R. NICOLAUS
“ISF research topics and symbiotic approach to drug design”.
1st JAPANESE-ITALIAN PHARMACOLOGICAL MEETING – Tokyo, Japan, 18-19 April 1983.
88. BRUNO J.R. NICOLAUS
International Meeting on: “New strategies for orphan drugs – economical aspects”.
National Academy of Sciences (XL) – Rome March 1985.
89. BRUNO J.R. NICOLAUS
“Procédé de préparation de dérivés de chroméne”.
Pat. Luxembourg 72.297.
90. BRUNO J.R. NICOLAUS
“Pharmaceutical Research: problems and interaction between Academia and Industry”.
Symposium on the Italian Society for Pharmaceutical Sciences – Rome 1984 – Documento SISF 18, 1984.
91. BRUNO J.R. NICOLAUS
“Rediscover the forgotten brain: new drugs in learning and memory – Oxiracetam, a new nootropic in Alzheimer and other dementias”.
The Fourth Congress of the International Psychogeriatric Association
Tokyo, Japan, September 1989.
92. BRUNO J.R. NICOLAUS
“Rediscover the forgotten brain: new drugs in learning and memory”.
World Federation for Mental Health – Nile Cruise World Congress Luxor-Aswan January 1989: “The State of Art in Mental Health and Biological Psychiatry”.
93. BRUNO J.R. NICOLAUS
“Rediscover the forgotten brain: new drugs in Alzheimer and other dementias”.
Fourth Panarab Congress on Psychiatry, Sana’s – Yemen December 1989.
94. BRUNO J.R. NICOLAUS
“Topical use of calcitonin for the preparation of medications in senile idiopathic cataract and a pharmaceutical composition thereof”.
Patent
USA
:
5.279.836
Date
1994
95. BRUNO J.R. NICOLAUS
“E’ ora di riscoprire il cervello, organo negletto”.
Incontri ISF – Anno 2, no. 5, Febbraio 1990.
96. BRUNO J.R. NICOLAUS
“Uomo-animale-natura nell’evolversi dei secoli” .
ATTI DELLA ACCADEMIA PONTANIANA, NUOVA SERIE VOL. XLIII, 55-96, 1994 Edizioni Giannini Napoli.
97. BRUNO J.R. NICOLAUS
“Bioecological aggression and the brain”.
INTEGRATIVE PSYCHIATRY VOL. 9, 3-4, 1993 – Internat. Universities Press, Inc.
98. BRUNO J.R. NICOLAUS, RODOLFO A. NICOLAUS
“L’aggressione dell’ambiente al cervello dell’uomo”.
QUADERNI DELL’ACCADEMIA PONTANIANA VOL. 14, 1-55, 1992.
Edizioni Giannini Napoli.
Recensioni Giornalistiche:
– “Le conseguenze dell’aggressione dell’ambiente al cervello dell’uomo” – GAZZETTA SVIZZERA, Lugano Nr. 2, Febbraio 1993;
– “Vom Homo sapiens zum Homo novus” – BÜNDNER TAGBLATT, Chur – 72, Pag. 6, 27 marzo 1993;
– “Il cervello dell’uomo aggredito dall’ambiente” – IL GLOBO, Roma, Nr. 4, 8 gennaio 1994;
– “Con la testa tra i veleni” – IL MATTINO, Napoli, Anno 103, Pag. 18, 17 febbraio 1994.
99. BRUNO J.R. NICOLAUS
Symbiotic approach to drug design – in DECISION MAKING IN DRUG RESEARCH.
Edited by Franz Gross – RAVEN PRESS NEW YORK – 173-188, 1983.
100. BRUNO J.R. NICOLAUS
“Alla riscoperta del cervello, organo negletto, tesoro nascosto”
RASSEGNA ARTISTICO LETTERARIA DELLA ASSOCIAZIONE SANITARI LETTERATI ARTISTI ITALIANI (ASLAI) – ANNO VIII, NR. 3, NOV. 1993 – Tipografia Squassina Brescia.
101. BRUNO J.R. NICOLAUS
“Guazzo dell’isola verde in una giornata di calura ( … Pure i leoni devono mangiare …).
LA RASSEGNA D’ISCHIA XVI, NR. 2, 1995.
102. BRUNO J.R. NICOLAUS
“Il trionfo dei farmaci effimeri, ma qualcuno serve davvero”.
CORRIERE DELLA SALUTE, Settimanale del CORRIERE DELLA SERA Milano, Pag. 3, 20 Dicembre 1993.
103. BRUNO J.R. NICOLAUS
“Con una dozzina di farmaci abbiamo sconvolto il mondo”.
GAZZETTA SVIZZERA Lugano 3, 1994.
104. BRUNO J.R. NICOLAUS
“Danzan le ombre sotto le cime”.
Quaderni Grigionitaliani Anno 65, 1996 in stampa.
105. BRUNO J.R. NICOLAUS
“L’arca di Noè. Le invenzioni della natura e della cultura”
Prometheus 21, (1995) pag. 1-151 Franco Angeli, Milano 1996
106. BRUNO J.R. NICOLAUS
“La cultura dell’inganno, parte I, Guazzo della civiltà mediterranea”.
La rassegna d’Ischia 7 (1996), 1-58.
107. BRUNO J.R. NICOLAUS
“La cultura dell’inganno, parte II, Riflessioni sull’evoluzione del cervello e delle culture” –
Accademia Pontaniana Quaderno 21, 1-85 (1997).
108. BRUNO J.R. NICOLAUS – RODOLFO A. NICOLAUS
“Speculating on the Band Colours in Nature”
Atti Accademia Pontaniana 45, 365-385 (1996).
109. BRUNO J.R. NICOLAUS
“Eutanasia del dolore e della coscienza. Riflessioni sulla rivoluzione biomedica e sul dilagar di droga e violenza”
Atti Accademia Pontaniana 46, 379-411 (1997).
110. BRUNO J.R. NICOLAUS
“Ma l’homo sapiens sapiens è proprio così sapiens?”
Atti Accademia Pontaniana 46, 474-480 (1997).
111. BRUNO J.R. NICOLAUS
“Invecchiamento cerebrale, neuro e psicopatie: genesi sviluppo alla luce della chimica patologica” (Speculations on the pathological chemistry of brain aging, neuro and psychopathies)
Atti Accademia Pontaniana 47, (1998) 245-271.
112. BRUNO J.R. NICOLAUS. RODOLFO A. NICOLAUS
“Melanins, biological garbage or jewel”
Scientific communication presented at the 8th meeting of the European Society for Pigment Cell Research – Sept. 23-26 (1998), Prague – Pigement cell research vol. 11, Nr 4, page 233 (1998).
113. BRUNO J.R. NICOLAUS E RODOLFO A. NICOLAUS
“Chimica e fisica delle melanine” Poster (P42) presentato al IV convegno nazionale giornate di chimica delle sostanze naturali, – nat 4, Salerno 24-26 settembre 1997.
114. BRUNO J.R. NICOLAUS, RODOLFO A. NICOLAUS, MARCO OLIVIERI
“Riflessioni sulla chimica della materia nera interstellare”
Rend. Acc. Sc. Fis. Mat. Napoli vol LXVI, (1999), pp. 113-129.
115. BRUNO J.R. NICOLAUS
“Risucchiati dal vortice oscuro – Riflessioni sulla chimica patologica e la neurobiologia del suicidio”
Atti Accademia Pontaniana vol. XLVIII (1999) 199-231.
116. BRUNO J.R. NICOLAUS, RODOLFO A. NICOLAUS
“Lo scrigno oscuro della vita – Riflessioni sul ruolo chimico-biologico della materia nera interstellare e sulla comparsa della vita nell’universo”
Atti Accademia Pontaniana vol. XLVIII (1999), 355-380.
117. BRUNO J.R. NICOLAUS
“Bettina – L’arte del cogliere l’attimo, la magia dell’arrestare il tempo “
La rassegna d’Ischia, nr. 6 (1999), 21-31.
118. BRUNO J.R. NICOLAUS
“Verso il futuro, a piccoli passi , ma l’avventura continua”
Gazzetta Svizzera , 32 nr.12 (2001), 9-10
119. BRUNO J.R. NICOLAUS
“Verso il futuro, a piccoli passi”
Rassegna artistico letteraria ASLAI , 15 Nr.2 (2001), 12-15; Atti Accademia Pontaniana, vol. L (2001) pp. 394-400
120. BRUNO J.R. NICOLAUS
“Globalizzazione,una sfida biologico culturale”
Atti Accademia Pontaniana vol. LI (2002) , 21-26
121. BRUNO J.R. NICOLAUS
“Malattie molecolari, la maledizione del terzo millennio”
Gazzetta Svizzera, 33 nr.2 (2002),10
122. BRUNO J.R. NICOLAUS
“Molecular diseases, the plague of the third millennium”
on line: www.brunonic.org
123. BRUNO J.R. NICOLAUS
“Globalization, a biological and cultural challenge”
on line: www.brunonic.org
124. BRUNO J.R. NICOLAUS
“Malattie molecolari”
Accademia Pontaniana Quaderno nr.34, (2002) , pp. 1-120;
on line: www.brunonic.org
125. BRUNO J.R. NICOLAUS
“Verso il futuro a piccoli passi”
Atti Accademia Pontaniana vol.L (2001), pp. 394-400
126. BRUNO J.R. NICOLAUS, GIORGIO TANGORRA
“Dalle Stelle al Pensiero”
Atti Accademia Pontaniana, vol.LI (2002), 325-349
127. BRUNO J.R. NICOLAUS, GIORGIO TANGORRA
“La Vita cosa è, cosa fa-alcune Riflessioni”
Atti Accademia Pontaniana, vol LI (2002), 461-463
128. BRUNO J.R. NICOLAUS, GIORGIO TANGORRA
“From the stars to thought” (2002)
online: www.brunonic.org
129. BRUNO J.R. NICOLAUS
“Globalisation in biology“
NEW YORK Academy of Sciences, Update 11 (2003), Member News.
130. BRUNO J.R. NICOLAUS
“Holz, ein Wunder der Naturchemie“ Referat anlaesslich der Konferenz des ALPENFORUM: “Innovative Holzverarbeitung, ein Beitrag zur nachhaltigen Entwicklung im Alpenraum“,
Murau,Steiermark (Oesterreich), Juni 2003.
online www.brunonic.org; www.alpenforum.org
131. BRUNO J.R. NICOLAUS
“Un Capitan Generale protestante alla cattolicissima Corte del Regno delle due Sicilie“
La Rassegna d’Ischia 2/2003; La Gazzetta Svizzera 34/nr.6 (giugno 2003);
“A protestant Swiss commander-in-chief at the very observant catholic court of the Kingdom of Naples and both Sicily“; “Ein reformierter Schweizer Kommandant am streng katholischen Hof vom Koenigreich beider Sizilien“
online: www.brunonic.org
132. BRUNO J.R. NICOLAUS
“Health and molecular diseases – Speculating on the global spreading of molecular diseases: how should mankind react?“
Atti Accademia Pontaniana, Napoli LII (2003), pp. 285-293.
133. BRUNO J.R. NICOLAUS
“From Butterflies to Psychotropics – A Chemical Odyssey” in “Reflections on Twentieth-Century Psychopharmacology”
Eds. Thomas A. Ban, David Healy, Edward Shorter, (2004),Vol.4 pp.250-253 of the series “The History of Psychopharmacology and the CINP, As Told in Autobiography”,
Publ. ANIMULA, BUDAPEST 2004.
134. BRUNO J.R. NICOLAUS
“Neuromelanin and biological function- Sulle neuromelanine e loro ruolo biologico”
Atti Accademia Pontaniana, Napoli LIII (2004), pp.251-281.
135. BRUNO J.R. NICOLAUS
“From Butterflies to Psychotropics-a Chemical Odyssey”
Atti Accademia Pontaniana, Napoli LIII (2004), pp.451-455.
136. BRUNO J.R. NICOLAUS
“A critical review of the function of neuromelanin and an attempt to provide a unified theory”
Medical Hypotheses (2005), 65, 791-796.
137. BRUNO J.R. NICOLAUS
“Le nubi nere interstellari, culla della vita nell’universo”
in stampa; on line www.brunonic.org.
138. BRUNO J.R. NICOLAUS
“Astrochimica e vita, un’ipotesi modulare”
Atti Accademia Pontaniana, Napoli LIV (2005),in corso di stampa.
139. BRUNO J.R. NICOLAUS
“Tre secoli di sangue e di gloria – I reggimenti svizzeri in servizio all’estero:Riflessi politico-culturali della loro attività riletti in chiave moderna“
in stampa; on line www.brunonic.org .
140. BRUNO J.R. NICOLAUS
“Melanins and Human Brain – Reviewing critically the biological role and Speculating on an unified mechanism“ V – Magistral Lecture at the “Congreso Regional Latinoamericano del Colegio Internacional de Neuropsicofarmacologia (CINP)”
Lima, Perù 25-29 Nov.2005; online www.brunonic.org.