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Curriculum socio





- Nicolaus Bruno J. R. -


Born 1928.

- Ph.D. in Organic Chemistry, University of Zürich (CH), Faculty of Sciences (1954).

Assistant to Nobel Prize Laureate Prof. Paul Karrer University of Zürich (1949-1952);Lecturer of Organic Chemistry University of Milano Italy (1962-1970); Associate Professor of Pharmaceutical Chemistry University of Perugia Italy (1978); Pharmaceutical Industrial Advisor to the United Nations (1966).

More than 100 publication and 50 patents.  Fluent in Italian, German, French English and Spanish.

- Member of several cultural and scientific associations:  New Swiss Chemical Society; Società Italiana di Scienze Farmaceutiche (SISF); International College of Neuropsychopharmacology (CINP); European College of Neuropsychopharmacology (ECNP); International Psychogeriatric Association (IPA); Academia Medicinae et Psychiatriae Foundation – New York; Associazione Italiana Malattia di Alzheimer – AIMA; Society of Literature and Science – John Hopkins University Baltimore USA; Associazione Sanitari Artisti Letterati Italiani (ASLAI); Associate Editor of Integrative Psychiatry; Swiss Society of the History of Medicine and Sciences; Gruppo Nazionale di Fondamenti e Storia della Chimica, GNFSC; Chemical Heritage Foundation –The Beckman Center for History of Chemistry Philadelphia USA; Centro di Studi Storici Valchiavennaschi, Pro Raetia; Verein Kulturraum Viamala; CICAP – Scienza e Paranormale; Accademia Pontaniana Napoli; New York Academy of Sciences.

- Attended various international congresses dealing with drug research and development (chemistry, biology, pharmacology, clinics, economics).

 

Main scientific interests:

 

1948 -      Chemical Pathology of the Brain, Neuropsychopharmacology, Learning and Memory, Brain Ageing, Antibiotics and Infections, Natural and Synthetic Pigments

 

Main achievements:

 

1950 - 1953 University of Zurich CH, Institute for Organic Chemistry (Prof. Paul Karrer):

Structure an synthesis of synthetic and natural pteridin pigments; new synthesis  of biological polyamines from peptides, with lithiumaluminiumhydrid.

1954 - 1960      SANDOZ Basle: Research Chemist.

Synthesis of styryl-derivatives with peculiar structure/colour properties; improvement and application of TLC (thinlayerchromatography) to synthetic and natural pigments.

1960 - 1969      DOW-LEPETIT Milano:  Senior Scientist, Director of new products development.

Separation and identification of transformation products of Rifamycin B; New microbiological determination of antibiotics on thinlayerchromatograms; synthesis of new organic hydroxylaminderivatives and new 4,5- and 7-membered heterocyclic compounds potentially active on the CNS; international development of new drugs: Rifamycin antibiotics (Rifamycin SV, Rifamide, Rifampicin); vitamin preparations in new dosage forms (agruvit, orangrip); spironolactone–diuretic, ovulen-contraceptive, amitryptiline –antidepressant, metoclopramide and sulpiride – peristalsis modulators.

1969 - 1990 ISF CORPOR (ISF, one of the leading Italian Pharma Companies belonging to the SMITHKLINE BEECHAM GROUP):

Vice President for Research and Development; Vice President of Innovation; Deputy General Manager; Vice President of the Board of Directors.

International Development of New Drugs:  Pyrrolnitrin – antifungal, Bekanamycin – antibiotic, Trithiozine – antiulcer, Piromidic and Pipemidic acid, Norfloxacin – quinolonic antibacterials, Trimetoquinolbronchodilator, carbocalcitonin – calcium metabolism, Metolazone – diuretic, Cadralazine –antihypertensive, Oxiracetam – nootropic, Cefonicid – antibiotic, Rokitamycine –antibiotic.

1990 - 1995 MEDIATOR PHARMA CONSULTANTS (Agency for the development and licensing of new drugs and acquisition of companies): Chairman of the Scientific Advisory Board.

Studies on braindisfunctions and history of science; active participation to the decade of the brain activities (CINP; ECNP, IPA).

1996  -          Free lancer and scientific consultant.

                    Further studies on history of science an braindevelopment; neuropsychopharmacology of brain pathologies and behaviour disturbances; New hypothesis on the causes of suicide and molecular disease of the brain; astrochemistry; speculations on the chemical nature of interstellar clouds and the origin of life in the universe.

 

Main Publications

 

1.    P. KARRER, R. SCHWYZER, BRUNO J.R. NICOLAUS

80. Weitere Methyl-pteridinrot-ähnliche Farbstoffe aus verschiedenen Methyl-pteridinen und Pteridin.

 

HELV. CHIM. ACTA, 33, 557, 1950.

2.    P. KARRER, BRUNO J.R. NICOLAUS, R. SCHWYZER

       158. Über die Konstitution des Methyl-pteridinrots.

       HELV. CHIM. ACTA, 33, 1233, 1950.

 

3.    P. KARRER, BRUNO J.R. NICOLAUS

       125. Zur Kenntnis des Methyl-pteridinrots, Pteridinrots und ähnlicher Farbstoffe.

       HELV. CHIM. ACTA, 34, 1029, 1951.

 

4.    P. KARRER, BRUNO J.R. NICOLAUS

       199. Reduktionen einiger einfacher Peptide mit Lithiumaluminiumhydrid.

       HELV. CHIM. ACTA, 35, 1581, 1952.

 

5.     BRUNO J.R. NICOLAUS

       I. Zur Kenntnis der Pteridinrot-Reihe und ähnlicher Farbstoffe.

       II. Aliphatische Polyamine.

       Inaugural-Dissertation der Universität von Zürich.

       Brunner & Bodmer, Zürich 1954.

 

6.     BRUNO J.R. NICOLAUS

       "Anwendung der Dünnschichtchromatographie auf Pteridine".

       J.CHROMATOGR., 4, 384, 1960.

 

7.     BRUNO J.R. NICOLAUS

       "Nuovi coloranti a dispersione. Nota I. - Monoazoici gialli contenenti gruppi uretanici".

       REND. DELL'ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA' NAZIONALE DI SCIENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 105, 1960.

 

8.     BRUNO J.R. NICOLAUS

       "Nuovi coloranti a dispersione. Nota II. - Eteri di monoazoici gialli contenenti gruppi uretanici".

       REND. DELL'ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA' NAZIONALE DI SCIENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 122, 1960.

 

9.     BRUNO J.R. NICOLAUS

       "Nuovi coloranti a dispersione. Nota III. - Ammine aromatiche terziarie contenenti gruppi uretanici".

       REND. DELL'ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA' NAZIONALE DI SCIENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 132, 1960.

 

10.     BRUNO J.R. NICOLAUS

       "Nuovi coloranti a dispersione. Nota IV. - Monoazoici rossi contenenti gruppi uretanici".

       REND. DELL'ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA' NAZIONALE DI SCIENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 142, 1960.

 

11.     BRUNO J.R. NICOLAUS

       "Nuovi coloranti a dispersione. Nota V - Coloranti stirilici contenenti gruppi uretanici".

       REND. DELL'ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA' NAZIONALE DI SCIENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 297, 1960.

 

12.     BRUNO J.R. NICOLAUS

       "Nuovi coloranti a dispersione. Nota VI - Nuovi composti stirilici e relazioni intercorrenti tra costituzione chimica e proprietà ottiche".

       REND. DELL'ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA' NAZIONALE DI SCIENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 320, 1960.

 

13.     BRUNO J.R. NICOLAUS

       "Nuovi coloranti a dispersione. Nota VII - Composti stirilici basici e relazioni intercorrenti tra costituzione chimica e spettri di assorbimento".

       REND. DELL'ACCADEMIA DI SCIENZE FISICHE E MATEMATICHE DELLA SOCIETA' NAZIONALE DI SICENZE, LETTERE ED ARTI IN NAPOLI, Serie 4, 27, 480, 1960.

 

14.  P. SENSI, C. CORONELLI, BRUNO J.R. NICOLAUS

       "Rifomycin".

       XII. Chromatographic Studies of Some Products of Transformation of Rifomycin B.

       J. CHROMATOGR., 5, 519, 1961.

 

15.     BRUNO J.R. NICOLAUS, L. MARIANI, E. TESTA

       129. Auf das Zentralnervensystem wirkende Substanzen XXV Reaktionen der a-substituierten b-Lactone II. Eine neue allgemeine Synthese

       a-substituierter Propionsäuren und deren Derivate.

       HELV. CHIM. ACTA, 44, 1076, 1961.

 

16.     BRUNO J.R. NICOLAUS, L. MARIANI, E. TESTA

       256. Auf das Zentralnervensystem wirkende Substanzen XXVII Reaktionen mit a-substituierten b-Propiolactonen III. 4-Mono- und 4,4-disubstituierte 3-Pyrazolidinone.

       HELV. CHIM. ACTA, 44, 2059, 1961.

 

17.     BRUNO J.R. NICOLAUS, C. CORONELLI., A. BINAGHI

       "Applicazione agli antibiotici della cromatografia su strato sottile".

       FARMACO, Prat., 16, 349, 1961.

 

18.     BRUNO J.R. NICOLAUS, C. CORONELLI, A. BINAGHI

       "Mikrobiologischer Nachweis von Antibiotika auf Dünnschichtchroma-

       togrammen".

       EXPERIENTIA, 17, 473, 1961.

 

19.     BRUNO J.R. NICOLAUS, E. TESTA

       "Einfaches Verfahren zur Spaltung von Pikraten".

       ANGEWANDTE CHEMIE, 73, 655, 1961.

 

20.       BRUNO J.R. NICOLAUS, L. MARIANI, E. TESTA.

       Reaktionen mit a-substituierten b-Propiolactonen III. 4-Mono- und 4,4-disubstituierte 3-Pyrazolidinone.

       CHIMIA, 15, 577, 1961.

 

21.     BRUNO J.R. NICOLAUS, L. MARIANI, G. GALLO, E. TESTA

       Reactions with a-Substituted b-Propiolactones. I. 4,4-Disubstituted 2-Oxazolidinones.

       Research on Compounds Active on the Central Nervous System. XXIII^.

       J. ORG. CHEM., 26, 2253, 1961.

 

22.     BRUNO J.R. NICOLAUS, G. PAGANI, E. TESTA

       40.0, N-substituierte Hydroxylamine

       1. Mitteilung - Über das 0-(b-Hydroxyäthyl)-hydroxylamin, ein neuartiges Analogon von b-Aminoäthanol, und Derivate Untersuchungen über synthetische Arzneimittel I.

       HELV. CHIM. ACTA, 45, 358, 1962.

 

23.     BRUNO J.R. NICOLAUS, E. BELLASIO, E. TESTA.

       85. Auf das Zentralnervensystem wirkende Substanzen XXIX.

       Über neuartige schwefelhaltige Heterocyclen: 4,4-Dialkyl-1,2-thioazetidin-3-on-1,1-dioxide und 2,4,4-Trialkyl-1,2-thioazetidin-3-on-1,1-dioxide.

       HELV. CHIM. ACTA, 45, 717, 1962.

 

24.     BRUNO J.R. NICOLAUS, G. PAGANI, E. TESTA

       162.0,n-substituierte Hydroxylamine

       2.Mitteilung - Synthese und Eigenschaften der 0-(Phenylalkyl)-hydroxylamine.

       Untersuchungen über  synthetische Arzneimitteln II.

       HELV. CHIM. ACTA, 45, 1381, 1962.

 

25.     BRUNO J.R. NICOLAUS, E. BELLASIO, E. TESTA

       47. Auf das Zentralnervensystem wirkende Substanzen XXXV.

       Über neuartige schwefelhaltige Heterocyclen II: Synthese und Eigenschaften der 3-Alkoxy-4,4-dialkyl-4H-1,2-thiazet-1,1-dioxide.

       HLEV. CHIM. ACTA, 46, 450, 1963.

 

26.  E. TESTA, BRUNO J.R. NICOLAUS, L. MARIANI, G. PAGANI

       85. 0,N-substituierte Hydroxylamine V.Mitt.

       Über Synthese und Eigenschaften der a-Aminoxy-Carbonsäuren, Analoga natürlicher a-Aminocarbonsäuren.

       HELV. CHIM. ACTA, 46, 766, 1963.

 

27.     BRUNO J.R. NICOLAUS, E. BELLASIO, E. TESTA

       "Sull'acido fenilsolfonacetico e suoi derivati funzionali".

       ANNALI DI CHIMICA, 53, 14, 1963.

 

28.     BRUNO J.R. NICOLAUS, L. MARIANI, E. TESTA

       "Idrossilamine 0,N-sostituite.  Nota III. Una nuova sintesi delle 0-alchilidrossilamine. Ricerche su nuovi farmaci di sintesi 2.

       ANNALI DI CHIMICA, 53, 281, 1963.

 

29.     BRUNO J.R. NICOLAUS, L. MARIANI, G. PAGANI, MAFFII G. TESTA E.

       "Idrossilamine 0.N-sostituite. Nota IV. Sintesi ed attività di alcuni analoghi idrossilaminici di anestetici locali".

       ANNALI DI CHIMICA, 53, 290, 1963.

 

30.     BRUNO J.R. NICOLAUS, E. BELLASIO, G. PAGANI, E. TESTA.

       "Sintesi e proprietà degli N-alcossi ed N-idrossi-azetidin-2-oni".

       GAZZETTA CHIMICA ITALIANA, 93, 618, 1963.

 

31.     BRUNO J.R. NICOLAUS, L. MARIANI, E. BELLASIO, E. TESTA

       "Nuovi aspetti della chimica dei 3-pirazolidinoni 4-mono e 4,4-disostituiti".

       GAZZETTA CHIMICA ITALIANA, 94, 652, 1964.

 

32.  E. TESTA, BRUNO J.R. NICOLAUS, E. BELLASIO, L. MARIANI

       Auf das Zentralnervensystem wirkende Substanzen XXXVII 1-Alkyl- und 1-Aryl-Azetidinone-(2).

       JUSTUS LIEBIGS ANN. CHEM., 673, 71, 1964.

 

33.     BRUNO J.R. NICOLAUS, E. BELLASIO, E. TESTA

       New Pharmacologically Active Thiazetidine Compounds.

Patent

U.K.

:

963.500

Date

1964

 

34.     BRUNO J.R. NICOLAUS, E. TESTA

       New Anti-Bacterial 0-Hydroxy- or -Phenyl-Alkyloximes.

Patent

U.K.

:

964.721

Date

1964

 

35.     BRUNO J.R. NICOLAUS, E. TESTA

       Hydroxylamines substituées et procédés pour leur préparation.

Patent

France

:

1.320.965

Date

1963

   "

Germany

:

1.148.559

Date

1963

   "

Austria

:

23.30.01

Date

1964

 

36.     BRUNO J.R. NICOLAUS, E. TESTA

       4,4-Disubstituted 3-Pyrazolidinones and Therapeutic Compositions Containing the Same.

Patent

USA

:

3.166.568

Date

1965

   "

U.K.

:

1.022.861

Date

1966

 

37.  E. MERIAN, BRUNO J.R. NICOLAUS, W. WEHRLI

       Water-Insoluble Monoazo Dyestuffs.

Patent

USA

:

2.831.850

Date

1958

   "

France

:

1.146.212

Date

1957

   "

Deutschland

:

1.061.924

Date

1960

   "

Schweiz

:

33.21.36

Date

1958

   "

U.K.

:

792.212

Date

1958

 

38.  E. MERIAN, BRUNO J.R. NICOLAUS

       Verfahren zur Herstellung wasserunlöslicher Monoazofarbstoffe.

Patent

Schweiz

:

34.09.27

Date

1959

   "

Schweiz

:

34.41.50

Date

1960

   "

Schweiz

:

34.41.51

Date

1960

   "

Schweiz

:

34.41.52

Date

1960

 

39.  E. MERIAN, BRUNO J.R. NICOLAUS, W. WEHRLI

       Water-Insoluble Monoazo Dyestuffs.

Patent

USA

:

2.870.137

Date

1959

   "

Schweiz

:

34.41.49

Date

1960

   "

Schweiz

:

35.85.31

Date

1962

   "

U.K.

:

816.308

Date

1959

 

40.     BRUNO J.R. NICOLAUS, E. MERIAN

       Water-Insoluble Monoazo Dyestuffs.

Patent

USa

:

2.864.816

Date

1958

   "

France

:

1.177.377

Date

1959

   "

Deutschland

:

1.061.925

Date

1959

   "

U.K.

:

807.696

Date

1959

   "

Schweiz

:

35.31.02

Date

1961

   "

Schweiz

:

34.84.92

Date

1960

 

41.  E. MERIAN, BRUNO J.R. NICOLAUS

       N-Substituted Urea and Carbamate Derivatives of Water-Insoluble

       Tertiary Amines.

Patent

USA

:

2.909.561

Date

1959

    "

France

:

1.216.235

Date

1960

    "

U.K.

:

845.220

Date

1960

   "

Schweiz

:

35.37.32

Date

1961

   "

Belgique

:

55.93.24

Date

1958

   "

Italia

:

63.28.54

Date

1962

 

42.  E. MERIAN, BRUNO J.R. NICOLAUS

       Water-Insoluble Azo Dyestuffs.

Patent

USA

:

3.069.408

Date

1962

   "

Deutschland

:

1.061.927

Date

1959

   "

U.K.

:

824.443

Date

1959

   "

Schweiz

:

34.57.05

Date

1960

   "

France

:

1.216.235

Date

1960

   "

Belgique

:

55.93.24

Date

1958

 

43.  E. MERIAN, BRUNO J.R. NICOLAUS, O. SENN

       New Water-Insoluble Stryryl Dyestuffs.

Patent

USA

:

2.850.520

Date

1958

   "

Deutschland

:

1.067.156

Date

1960

   "

Schweiz

:

35.85.34

Date

1962

   "

France

:

1.216.235

Date

1960

   "

U.K.

:

843.644

Date

1960

   "

Belgique

:

55.93.24

Date

1958

   "

Italia

:

57.73.74

Date

1956

   "

Japan

:

28.64.29

 

 

 

44.  E. MERIAN, BRUNO J.R. NICOLAUS, O. SENN

       Water-Insoluble Styryl Dyestuffs.

Patent

USA

:

2.936.319

Date

1960

   "

Deutschland

:

1.068.834

Date

1957

   "

U.K.

:

843.643

Date

1960

   "

France

:

1.187.779

Date

1959

   "

Schweiz

:

34.66.35

Date

1960

   "

Schweiz

:

35.16.96

Date

1961

   "

Schweiz

:

35.13.58

Date

1961

 

45.     EGGENBERGER H., E. MERIAN, BRUNO J.R. NICOLAUS

       Dyeing of Man-Made Fibers in the Mass.

Patent

U.K.

:

843.645

Date

1960

   "

Deutschland

:

1.061.955

Date

1960

   "

France

:

1.182.373

Date

1959

 

46.  E. MERIAN, BRUNO J.R. NICOLAUS, M. PERRIG, K. HOFER

       Verfahren zum Färben und Bedrucken von Gebilden aus Polymerisaten oder Mischpolymerisaten auf Basis von Acrylnitril oder Vinylidencyanid.

Patent

Deutschland

:

1.090.171

Date

1961

   "

France

:

1.206.872

Date

1960

   "

Schweiz

:

34.95.76

Date

1960

   "

U.K.

:

853.217

Date

1960

   "

Italia

:

589.933

Date

1959

 

47.  E. MERIAN, BRUNO J.R. NICOLAUS

       Azo Dyestuffs of Low Solubility in Water.

Patent

USA

:

2.980.666

Date

1961

   "

Deutschland

:

1.092.583

Date

1958

   "

U.K.

:

851.910

Date

1960

   "

Belgique

:

57.91.59

Date

1959

   "

France

:

76.452

Date

1961

 

48.     BRUNO J.R. NICOLAUS

       Verfahren zur Herstellung neuer wasserunlöslicher Styrylfarbstoffe.

Patent

Schweiz

:

35.13.59

Date

1961

   "

Belgique

:

57.30.04

Date

1958

 

49.  E. MERIAN, BRUNO J.R. NICOLAUS, W. WEHRLI

       Process for Dyeing Polyethylene Terephthalate of Fiber-Wool Blend.

Patent

USA

:

3.027.220

Date

1962

   "

France

:

1.215.973

Date

1960

   "

U.K.

:

895.427

Date

1962

   "

Schweiz

:

35.06.34

Date

1961

 

50.     BRUNO J.R. NICOLAUS

       Colorants de Dispersion, leurs procédés de fabrication et leurs applications.

Patent

Belgique

:

57.47.80

Date

1959

 

51.     BRUNO J.R. NICOLAUS

       Colorants de Dispersion, leurs procédés de fabrication et leurs applications.

Patent

Belgique

:

57.47.81

Date

1959

 

52.     BRUNO J.R. NICOLAUS, E. MERIAN

       Nouvelles amines primaires de la série benzothiazolique et colorants mono-azoiques qui en dérivent, leur fabrication et leurs applications.

Patent

France

:

1.220.194

Date

1960

   "

U.K.

:

868.037

Date

1961

   "

Deutschland

:

1.113.772

Date

1962

 

53.     BRUNO J.R. NICOLAUS

       Nouveaux colorants azoiques hydrosolubles, leur procédé de fabrication et leurs applications.

Patent

Belgique

:

57.99.65

Date

1959

   "

Italia

:

61.58.23

Date

1961

 

54.     BRUNO J.R. NICOLAUS

       Nouveaux colorants azoiques hydrosolubles, leur procédé de fabrication et leur préparation.

Patent

Belgique

:

58.01.61

Date

1959

   "

Italia

:

61.58.22

Date

1961

 

55.  R. HAHN, BRUNO J.R. NICOLAUS

       Verfahren zur Herstellung basischer Styrylfarbstoffe.

Patent

Deutschland

:

1.103.485

Date

1961

   "

France

:

1.240.138

Date

1960

   "

Belgique

:

58.23.16

Date

1959

   "

Italia

:

61.54.14

Date

1961

 

56.     BRUNO J.R. NICOLAUS

       Colorants basiques, leur procédé de fabrication et leurs applications.

Patent

France

:

1.240.748

Date

1960

   "

U.K.

:

931.557

Date

1963

   "

Belgique

:

58.30.02

Date

1959

   "

Italia

:

61.73.93

Date

1961

   "

Japan

:

30.85.42

 

 

 

57.     BRUNO J.R. NICOLAUS

       Verfahren zum Färben oder Bedrucken von textilen Gebilden aus Acrylnitrilpolymerisationsprodukten.

Patent

Schweiz

:

36.47.57

Date

1962

   "

Belgique

:

58.44.59

Date

1958

   "

Italia

:

62.58.62

Date

1961

 

58.     BRUNO J.R.NICOLAUS

       Nouveaux colorants azoiques quaternaires, leur procédé de fabrication et leurs applications.

Patent

France

:

1.244.711

Date

1960

   "

Belgique

:

58.53.85

Date

1959

   "

Italia

:

62.45.69

Date

1959

 

59.     BRUNO J.R. NICOLAUS

       Colorants basiques, leur procédé de fabrication et leurs applications.

Patent

France

:

1.246.068

Date

1960

   "

Belgique

:

58.66.34

Date

1960

   "

Japan

:

30.53.77

 

 

 

60.  E. MERIAN, BRUNO J.R. NICOLAUS, O. SENN, W. WEHRLI

       Colorants azoiques difficilement solubles dans l'eau, leurs procédés de fabrication et leurs applications.

Patent

France

:

1.264.972

Date

1961

   "

Belgique

:

59.36.44

Date

1960

   "

Italia

:

63.53.19

Date

1962

 

61.     BRUNO J.R. NICOLAUS, E. TESTA

       Process for preparing Hydroxylamines.

Patent

U.K.

:

986.213

Date

1965

   "

France

:

1.377.484

Date

1964

 

62.  E. TESTA, G. CIGNARELLA, G. PIFFERI, BRUNO J.R. NICOLAUS

       a,a -Disubstituted Propionic Acids and their Derivatives.

Patent

U.K.

:

988.934

Date

1965

 

63.  E. TESTA, G. CIGNARELLA, G. PIFFERI, BRUNO J.R. NICOLAUS

New Penicillins.

Patent

U.K.

:

988.933

Date

1965

   "

USA

:

3.280.111

Date

1960

   "

Deutschland

:

1.195.755

Date

1965

   "

Schweiz

:

411.892

Date

1966

 

64.     BRUNO J.R. NICOLAUS, E. TESTA

       0-(b-Acyloxyethyl)-N,N-Dialkyl-Hydroxylamines.

Patent

USA

:

3.184.500

Date

1965

   "

Austria

:

23.30.01

Date

1962

   "

France

:

1.320.965

Date

1963

   "

U.K.

:

1.017.601

Date

1966

 

65.  E. TESTA, BRUNO J.R. NICOLAUS

       Procédé de préparation des 2-azétidinones substituées en position 1.

Patent

France

:

1.393.833

Date

1965

   "

Austria

:

25.03.74

Date

1966

 

66.     BRUNO J.R. NICOLAUS, E. BELLASIO, G. PAGANI, L. MARIANI, E. TESTA

       201. Über eine neue allgemeine Synthese von 3,3-disubstituierten 2,3,4,5-Tetrahydro-1H-(benzo [b] 1.4-diazepin)-2-onen durch Ringerweiterung 3,3-disubstituierter 1-(o-Aminophenyl)-azetidin-2-one.

       HELV. CHIM. ACTA, 48, 1867, 1965.

 

67.     BRUNO J.R. NICOLAUS, E. TESTA

       Process for the preparation of Hydroxylamine Derivatives.

Patent

U.K.

:

1.042.191

Date

1966

 

68.     BRUNO J.R. NICOLAUS, E. TESTA

       Beta-Dialkylaminoxyethyl Esters of Substituted Benzoic Acids.

Patent

U.K.

:

1.017.602

Date

1966

 

 

69.     BRUNO J.R. NICOLAUS

       "Pteridin Chemistry".

       Lectures held at the University of Milan 1962-1963.

 

70.     BRUNO J.R. NICOLAUS

       "Recent acquisitions in antibiotics chemistry - The Tetracyclines".

       Lectures held at the University of Milan - 1963-1964.

 

71.     BRUNO J.R. NICOLAUS

       "Recent acquisitions in antibiotics chemistry - The Penicillins and Rifamycins".

       Lectures held at the University of Milan - 1964-1965.

 

72.     BRUNO J.R. NICOLAUS

       "Relationships between structure and activity".

       Lectures held at the University of Milan - 1965-1966.

 

73.     BRUNO J.R. NICOLAUS

       "Phenyl- and Bisphenylisochinolinalkaloids".

       Lectures held at the University of Milan - 1966-1967.

 

74.     BRUNO J.R. NICOLAUS

       "The antibiotics: an integrated approach on their chemistry, microbiology, pharmacology, and therapeutic application".

       Lectures held at the University of Perugia - 1988-1989.

 

75.     BRUNO J.R. NICOLAUS

       "New findings in the field of cognitive activators".

       Lectures held at the University of Perugia - 1988.

 

76.     BRUNO J.R. NICOLAUS

       "Tematiche di ricerca sviluppate dai Laboratori I.S.F. - Italseber negli ultimi sette anni".

       Atti del Simposio Internazionale GIRF/SISF la Ricerca Scientifica nell'Industria Farmaceutica in Italia - Risultati e Ruolo Internazionale - Roma, 2-4 Ottobre 1975.

 

77.     BRUNO J.R. NICOLAUS

       "Research Thematics Developed by I.S.F. - Italseber Laboratories over the Last Seven Years".

       International Symposium GIRF/SISF Scientific Research in the Pharmaceutical Industry in Italy - Results and International Role - Emme Print, Milan 1976.

 

78.     BRUNO J.R. NICOLAUS

       "Research Thematics Developed by ISf-Italseber Laboratories over the Last Seven Years" ISF-Laboratories for biomedical research, 1-31, 1975 - Tipografia Artigianelli.

 

79.     BRUNO J.R. NICOLAUS

       "Beitrag zur Chemie Organischer Hydroxylaminderivate".

       Bodmer Offset Verlag, Zürich 1976.

 

80.     BRUNO J.R. NICOLAUS

       "Beitrag zur Synthese von 4,5 und 7-Gliedrigen Heterocyclen mit einem Quartären Kohlenstoffatom".

       Bodmer Offset Verlag, Zürich 1976.

 

81.     BRUNO J.R. NICOLAUS

       "La ricerca, cofattore essenziale dello sviluppo di un'azienda".

       Convegno FAST/IMI: Per una Politica dell'Innovazione Tecnologica in Italia. Esperienze e Prospettive del Fondo per la Ricerca Applicata.

       Roma, 5-6 Dicembre 1977.

 

82.     BRUNO J.R. NICOLAUS

       "Research Topics 1969-1978".

       ISF Laboratories for biomedical research - 1-66, 1979- Tipografia Artigianelli Milano.

 

83.     BRUNO J.R. NICOLAUS

       "Aspetti e prospettive della chimica farmaceutica".

       I Convegno Nazionale - Divisione di Chimica Farmaceutica della Società Chimica Italiana - Pisa, 13-15 Dicembre 1979.

 

84.  F. SPARATORE, R. CAPASSO, M. MARCHETTI, BRUNO J.R. NICOLAUS, L. PARISELLA, V. TORTORELLA.

       "Didattica e realtà professionale nel settore della chimica farmaceutica".

       Tavola Rotonda

       II Convegno Nazionale - Divisione di Chimica Farmaceutica della Società Chimica Italiana - Padova, 18-20 Dicembre 1980.

 

85.     BRUNO J.R. NICOLAUS

       "Chemistry and pharmacology of nootropics".

       DRUG DEVELOPMENT RESEARCH, 2, 463-474, 1982, Editor Alan R. Liss Inc.

 

86.     BRUNO J.R. NICOLAUS

       "Research Topics 1969-1982".

       ISF - Laboratories for Biomedical Research 1-78, 1982, Grafiche F.G.F. Milano.

 

87.     BRUNO J.R. NICOLAUS

       "ISF research topics and symbiotic approach to drug design".

       1st JAPANESE-ITALIAN PHARMACOLOGICAL MEETING - Tokyo, Japan, 18-19 April 1983.

 

88.     BRUNO J.R. NICOLAUS

       International Meeting on: "New strategies for orphan drugs - economical aspects".

       National Academy of Sciences (XL) - Rome March 1985.

 

89.     BRUNO J.R. NICOLAUS

       "Procédé de préparation de dérivés de chroméne".

       Pat. Luxembourg 72.297.

 

90.     BRUNO J.R. NICOLAUS

       "Pharmaceutical Research: problems and interaction between Academia and Industry".

       Symposium on the Italian Society for Pharmaceutical Sciences - Rome 1984 - Documento SISF 18, 1984.

 

91.     BRUNO J.R. NICOLAUS

       "Rediscover the forgotten brain: new drugs in learning and memory - Oxiracetam, a new nootropic in Alzheimer and other dementias".

       The Fourth Congress of the International Psychogeriatric Association

       Tokyo, Japan, September 1989.

 

92.     BRUNO J.R. NICOLAUS

       "Rediscover the forgotten brain: new drugs in learning and memory".

       World Federation for Mental Health - Nile Cruise World Congress Luxor-Aswan January 1989: "The State of Art in Mental Health and Biological Psychiatry".

 

93.     BRUNO J.R. NICOLAUS

       "Rediscover the forgotten brain: new drugs in Alzheimer and other dementias".

       Fourth Panarab Congress on Psychiatry, Sana's - Yemen December 1989.

 

94.     BRUNO J.R. NICOLAUS

       "Topical use of calcitonin for the preparation of medications in senile idiopathic cataract and a pharmaceutical composition thereof".

Patent

USA

:

5.279.836

Date

1994

 

95.     BRUNO J.R. NICOLAUS

       "E' ora di riscoprire il cervello, organo negletto".

       Incontri ISF - Anno 2, no. 5, Febbraio 1990.

 

96.     BRUNO J.R. NICOLAUS

       "Uomo-animale-natura nell'evolversi dei secoli" .

       ATTI DELLA ACCADEMIA PONTANIANA, NUOVA SERIE VOL. XLIII, 55-96, 1994 Edizioni Giannini Napoli.

 

97.     BRUNO J.R. NICOLAUS

       "Bioecological aggression and the brain".

       INTEGRATIVE PSYCHIATRY VOL. 9, 3-4, 1993 - Internat. Universities Press, Inc.

 

98.     BRUNO J.R. NICOLAUS, RODOLFO A. NICOLAUS

       "L'aggressione dell'ambiente al cervello dell'uomo".

       QUADERNI DELL'ACCADEMIA PONTANIANA VOL. 14, 1-55, 1992.

       Edizioni Giannini Napoli.

       Recensioni Giornalistiche:

                -     "Le conseguenze dell'aggressione dell'ambiente al cervello dell'uomo" - GAZZETTA SVIZZERA, Lugano Nr. 2, Febbraio 1993;

                -     "Vom Homo sapiens zum Homo novus" - BÜNDNER TAGBLATT, Chur - 72, Pag. 6, 27 marzo 1993;

                -     "Il cervello dell'uomo aggredito dall'ambiente" - IL GLOBO, Roma, Nr. 4, 8 gennaio 1994;

                -     "Con la testa tra i veleni" - IL MATTINO, Napoli, Anno 103, Pag. 18, 17 febbraio 1994.

 

99.     BRUNO J.R. NICOLAUS

       Symbiotic approach to drug design - in DECISION MAKING IN DRUG RESEARCH.

       Edited by Franz Gross - RAVEN PRESS NEW YORK - 173-188, 1983.

 

100. BRUNO J.R. NICOLAUS

       "Alla riscoperta del cervello, organo negletto, tesoro nascosto"

       RASSEGNA ARTISTICO LETTERARIA DELLA ASSOCIAZIONE SANITARI LETTERATI ARTISTI ITALIANI (ASLAI) - ANNO VIII, NR. 3, NOV. 1993 - Tipografia Squassina Brescia.

 

101. BRUNO J.R. NICOLAUS

       "Guazzo dell'isola verde in una giornata di calura ( ... Pure i leoni devono mangiare ...).

       LA RASSEGNA D'ISCHIA XVI, NR. 2, 1995.

 

102. BRUNO J.R. NICOLAUS

       "Il trionfo dei farmaci effimeri, ma qualcuno serve davvero".

       CORRIERE DELLA SALUTE, Settimanale del CORRIERE DELLA SERA Milano, Pag. 3, 20 Dicembre 1993.

 

103. BRUNO J.R. NICOLAUS

       "Con una dozzina di farmaci abbiamo sconvolto il mondo".

       GAZZETTA SVIZZERA Lugano 3, 1994.

 

104. BRUNO J.R. NICOLAUS

       "Danzan le ombre sotto le cime".

       Quaderni Grigionitaliani Anno 65, 1996 in stampa.

 

105. BRUNO J.R. NICOLAUS

       “L’arca di Noè.  Le invenzioni della natura e della cultura” 

       Prometheus 21, (1995) pag. 1-151 Franco Angeli, Milano 1996

 

106. BRUNO J.R. NICOLAUS

       “La cultura dell’inganno, parte I, Guazzo della civiltà mediterranea”.

       La rassegna d’Ischia 7 (1996), 1-58.

 

107. BRUNO J.R. NICOLAUS

       “La cultura dell’inganno, parte II, Riflessioni sull’evoluzione del cervello e delle culture” –

       Accademia Pontaniana Quaderno 21, 1-85 (1997).

 

108. BRUNO J.R. NICOLAUS – RODOLFO A. NICOLAUS

       “Speculating on the Band Colours in Nature”

       Atti Accademia Pontaniana 45, 365-385 (1996).

 

109. BRUNO J.R. NICOLAUS

       “Eutanasia del dolore e della coscienza.  Riflessioni sulla rivoluzione biomedica e sul dilagar di droga e violenza”

       Atti Accademia Pontaniana 46, 379-411 (1997).

 

110. BRUNO J.R. NICOLAUS

       “Ma l’homo sapiens sapiens è proprio così sapiens?”

       Atti Accademia Pontaniana 46, 474-480 (1997).

 

111. BRUNO J.R. NICOLAUS

       “Invecchiamento cerebrale, neuro e psicopatie:  genesi sviluppo alla luce della chimica patologica” (Speculations on the pathological chemistry of brain aging, neuro and psychopathies)

       Atti Accademia Pontaniana 47, (1998) 245-271.

 

112.  BRUNO J.R. NICOLAUS. RODOLFO A. NICOLAUS

“Melanins, biological garbage or jewel”

Scientific communication presented at the 8th meeting of the European Society for Pigment Cell Research – Sept. 23-26 (1998), Prague – Pigement cell research vol. 11, Nr 4, page 233 (1998).

 

113.  BRUNO J.R. NICOLAUS E RODOLFO A. NICOLAUS

“Chimica e fisica delle melanine” Poster (P42) presentato al IV convegno nazionale giornate di chimica delle sostanze naturali, - nat 4, Salerno 24-26 settembre 1997.

 

114.  BRUNO J.R. NICOLAUS, RODOLFO A. NICOLAUS, MARCO OLIVIERI

“Riflessioni sulla chimica della materia nera interstellare”

Rend. Acc. Sc. Fis. Mat. Napoli vol LXVI, (1999), pp. 113-129.

 

115.  BRUNO J.R. NICOLAUS

“Risucchiati dal vortice oscuro – Riflessioni sulla chimica patologica e la neurobiologia del suicidio”

Atti Accademia Pontaniana vol. XLVIII (1999) 199-231.

 

116.  BRUNO J.R. NICOLAUS, RODOLFO A. NICOLAUS

“Lo scrigno oscuro della vita - Riflessioni sul ruolo chimico-biologico della materia nera interstellare e sulla comparsa della vita nell’universo”

Atti Accademia Pontaniana vol. XLVIII (1999), 355-380.

 

117.  BRUNO J.R. NICOLAUS

          “Bettina – L’arte del cogliere l’attimo, la magia dell’arrestare il tempo “

La rassegna d’Ischia, nr. 6 (1999), 21-31.

 

118.  BRUNO J.R. NICOLAUS

“Verso il futuro,  a piccoli passi , ma l’avventura continua”

Gazzetta Svizzera , 32 nr.12 (2001), 9-10

 

119.  BRUNO J.R. NICOLAUS

“Verso il futuro, a piccoli passi”

Rassegna artistico letteraria ASLAI , 15 Nr.2 (2001), 12-15; Atti Accademia Pontaniana, vol. L (2001) pp. 394-400

 

120.  BRUNO J.R. NICOLAUS

“Globalizzazione,una sfida biologico culturale”

Atti Accademia Pontaniana vol. LI (2002) , 21-26

 

121.  BRUNO J.R. NICOLAUS

“Malattie molecolari, la maledizione del terzo millennio”

Gazzetta Svizzera, 33 nr.2 (2002),10

 

122.  BRUNO J.R. NICOLAUS

“Molecular diseases, the plague of the third millennium”

on line: www.brunonic.org

 

123.  BRUNO J.R. NICOLAUS

“Globalization, a biological and cultural challenge”

on line: www.brunonic.org

 

124.  BRUNO J.R. NICOLAUS

“Malattie molecolari”

Accademia Pontaniana  Quaderno nr.34, (2002) , pp. 1-120;

on line: www.brunonic.org

 

125.  BRUNO J.R. NICOLAUS

“Verso il futuro a piccoli passi”

Atti Accademia Pontaniana vol.L (2001), pp. 394-400

 

126.  BRUNO J.R. NICOLAUS, GIORGIO TANGORRA

“Dalle Stelle al Pensiero”

Atti Accademia Pontaniana, vol.LI (2002), 325-349

 

127.  BRUNO J.R. NICOLAUS, GIORGIO TANGORRA

“La Vita cosa è, cosa fa-alcune Riflessioni”

Atti Accademia Pontaniana, vol LI (2002), 461-463

 

128.  BRUNO J.R. NICOLAUS, GIORGIO TANGORRA

“From the stars to thought” (2002)

online: www.brunonic.org

 

129.  BRUNO J.R. NICOLAUS

“Globalisation in biology“

NEW YORK  Academy of Sciences, Update 11 (2003), Member News.

 

130.  BRUNO J.R. NICOLAUS

“Holz, ein Wunder der Naturchemie“ Referat anlaesslich der Konferenz des ALPENFORUM: “Innovative Holzverarbeitung, ein Beitrag zur nachhaltigen Entwicklung im Alpenraum“,

Murau,Steiermark (Oesterreich), Juni 2003.

online  www.brunonic.org;   www.alpenforum.org

 

131.  BRUNO J.R. NICOLAUS

“Un Capitan Generale protestante alla cattolicissima Corte del Regno delle due Sicilie“

La Rassegna d’Ischia 2/2003; La Gazzetta Svizzera 34/nr.6 (giugno 2003);

“A protestant Swiss commander-in-chief at the very observant catholic court of the Kingdom of Naples and both Sicily“; “Ein reformierter Schweizer Kommandant am streng katholischen Hof vom Koenigreich beider Sizilien“

online: www.brunonic.org

 

132.  BRUNO J.R. NICOLAUS

“Health and molecular diseases – Speculating on the global spreading of molecular diseases: how should mankind react?“

 Atti Accademia Pontaniana, Napoli LII (2003), pp. 285-293.

 

133.  BRUNO J.R. NICOLAUS

“From Butterflies to Psychotropics - A Chemical Odyssey” in “Reflections on Twentieth-Century Psychopharmacology”

Eds. Thomas A. Ban, David Healy, Edward Shorter, (2004),Vol.4 pp.250-253 of the series “The History of Psychopharmacology and the CINP, As Told in Autobiography”,

Publ. ANIMULA, BUDAPEST 2004.

 

134.  BRUNO J.R. NICOLAUS

“Neuromelanin and biological function- Sulle neuromelanine e loro ruolo biologico”

Atti Accademia Pontaniana, Napoli LIII (2004), pp.251-281.

 

135.  BRUNO J.R. NICOLAUS

“From Butterflies to Psychotropics-a Chemical Odyssey”

Atti Accademia Pontaniana, Napoli LIII (2004), pp.451-455.

 

136.  BRUNO J.R. NICOLAUS

“A critical review of the function of neuromelanin and an attempt  to provide a unified theory”

Medical Hypotheses (2005), 65, 791-796.

 

137.  BRUNO J.R. NICOLAUS

“Le nubi nere interstellari, culla della vita nell’universo”

in stampa; on line www.brunonic.org.

 

138.  BRUNO J.R. NICOLAUS

“Astrochimica e vita, un’ipotesi modulare”

Atti Accademia Pontaniana, Napoli LIV (2005),in corso di stampa.

 

139.  BRUNO J.R. NICOLAUS

“Tre secoli di sangue e di gloria - I reggimenti svizzeri in servizio all’estero:Riflessi politico-culturali della loro attività riletti in chiave moderna“

in stampa; on line www.brunonic.org .

 

140.  BRUNO J.R. NICOLAUS

“Melanins and Human Brain – Reviewing critically the biological role and Speculating on an unified mechanism“ V – Magistral Lecture at the “Congreso Regional Latinoamericano del Colegio Internacional de Neuropsicofarmacologia (CINP)”

Lima, Perù 25-29 Nov.2005; online www.brunonic.org.